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Florida mosquitoes: 750 million genetically modified insects to be released

Local officials in Florida have approved the release of 750 million mosquitoes that have been genetically modified to reduce local populations.

The aim is to reduce the number of mosquitoes that carry diseases like dengue or the Zika virus.

The green-lighting of a pilot project after years of debate drew a swift outcry from environmental groups, who warned of unintended consequences.

One group condemned the plan as a public "Jurassic Park experiment".

Activists warn of possible damage to ecosystems, and the potential creation of hybrid, insecticide-resistant mosquitoes.

But the company involved says there will be no adverse risk to humans or the environment, and points to a slate of government-backed studies.

The plan to release the mosquitoes in 2021 in the Florida Keys, a string of islands, comes months after the modified mosquitoes were approved by federal regulators.

In May, the US Environmental Agency granted permission to the British-based, US-operated company Oxitec to produce the genetically engineered, male Aedes aegypti mosquitoes, which are known as OX5034.

Aedes aegypti mosquitoes are known to spread deadly diseases to humans such dengue, Zika, chikungunya and yellow fever.

Only female mosquitoes bite humans because they need blood to produce eggs. So the plan is to release the male, modified mosquitoes who will then hopefully breed with wild female mosquitoes.

However the males carry a protein that will kill off any female offspring before they reach mature biting age. Males, which only feed on nectar, will survive and pass on the genes.

Over time, the aim is to reduce the population of Aedes aegypti mosquitoes in the area and thereby reduce the spread of disease to humans.

On Tuesday, officials in the Florida Keys Mosquito Control District (FKMCD) gave final approval to release 750 million of the modified mosquitoes over a two-year period.

The plan has many critics, including nearly 240,000 people who signed a petition on slamming Oxitec's plan to use US states "as a testing ground for these mutant bugs".

According to Oxitec's website, the company has found positive results conducting field trials in Brazil. It also plans to deploy them in Texas beginning in 2021 and has gained federal approval, but not state or local approval, according to reports.

In a statement denouncing the project, environmental group Friends of the Earth said: "The release of genetically engineered mosquitoes will needlessly put Floridians, the environment and endangered species at risk in the midst of a pandemic."

But an Oxitec scientist told AP news agency: "We have released over a billion of our mosquitoes over the years. There is no potential for risk to the environment or humans".

The Aedes aegypti is invasive to southern Florida, and are commonly found in urban areas where they live in standing pools of water. In many areas, including the Florida Keys, they have developed a resistance to pesticides.


Would it be wrong to eradicate mosquitoes?

The mosquito is the most dangerous animal in the world, carrying diseases that kill one million people a year. Now the Zika virus, which is carried by mosquitoes, has been linked with thousands of babies born with brain defects in South America. Should the insects be wiped out?

There are 3,500 known species of mosquito but most of those don't bother humans at all, living off plant and fruit nectar.

It's only the females from just 6% of species that draw blood from humans - to help them develop their eggs. Of these just half carry parasites that cause human diseases. But the impact of these 100 species is devastating.

"Half of the global population is at risk of a mosquito-borne disease," says Frances Hawkes from the Natural Resources Institute at the University of Greenwich. "They have had an untold impact on human misery."

Deadly mosquitoes

  • Aedes aegypti - spreads diseases including Zika, yellow fever and dengue fever; originated in Africa but is found in tropical and subtropical regions throughout the world

  • Aedes albopictus - spreads diseases including yellow fever and dengue fever and West Nile virus; originated in Southeast Asia but is now found in tropical and subtropical regions throughout the world

  • Anopheles gambiae (pictured above) - also known as the African malaria mosquito, the species is one of the most efficient transmitters for the spread of the disease

More than a million people, mostly from poorer nations, die each year from mosquito-borne diseases including malaria, dengue fever and yellow fever.

Some mosquitoes also carry the Zika virus, which was first thought to cause only mild fever and rashes. However, scientists are now worried it can damage babies in the womb. The Zika virus has been linked with a spike in microcephaly - where babies are born with smaller heads - in Brazil.

There's a constant effort to educate people to use treated nets and other tactics to avoid being bitten. But would it just be simpler to make an entire species of disease-carrying mosquito extinct?

Biologist Olivia Judson has supported "specicide" of 30 types of mosquito. She said doing this would save one million lives and only decrease the genetic diversity of the mosquito family by 1%. "We should consider the ultimate swatting," she told the New York Times.

In Britain, scientists at Oxford University and the biotech firm Oxitec have genetically modified (GM) the males of Aedes aegypti - a mosquito species that carries both the Zika virus and dengue fever. These GM males carry a gene that stops their offspring developing properly. This second generation of mosquitoes then die before they can reproduce and become carriers of disease themselves.

About three million of these modified mosquitoes were released on to a site on the Cayman Islands between 2009 and 2010. Oxitec reported a 96% reduction in mosquitoes compared with nearby areas. A trial currently taking place on a site in Brazil has reduced the numbers by 92%.

So are there any downsides to removing mosquitoes? According to Phil Lounibos, an entomologist at Florida University, mosquito eradication "is fraught with undesirable side effects".

He says mosquitoes, which mostly feed on plant nectar, are important pollinators. They are also a food source for birds and bats while their young - as larvae - are consumed by fish and frogs. This could have an effect further up and down the food chain.

However, some say that the role of mosquito species as food and pollinators would quickly be filled by other insects. "We're not left with a wasteland every time a species vanishes," Judson said.

But for Lounibos, the fact this niche would be filled by another insect is part of the problem. He warns that mosquitoes could be replaced by an insect "equally, or more, undesirable from a public health viewpoint". Its replacement could even conceivably spread diseases further and faster than mosquitoes today.

Science writer David Quammen has argued that mosquitoes have limited the destructive impact of humanity on nature. "Mosquitoes make tropical rainforests, for humans, virtually uninhabitable," he said.

Rainforests, home to a large share of our total plant and animal species, are under serious threat from man-made destruction. "Nothing has done more to delay this catastrophe over the past 10,000 years, than the mosquito," Quammen said.

But destroying a species isn't just a scientific issue, it's also a philosophical one. There would be some who would say it is utterly unacceptable to deliberately wipe out a species that is a danger to humans when it is humans that are a danger to so many species.

"One argument against is that it would be morally wrong to remove an entire species," says Jonathan Pugh, from Oxford University's Uehiro Centre for Practical Ethics.

And yet that's not an argument we apply to all species, says Pugh. "When we eradicated the Variola virus, which caused smallpox, we rightly celebrated.

"We need to ask ourselves, does it have any valuable capacities? For instance, is it sentient and therefore has the capacity to suffer pain? Scientists say mosquitoes don't have an emotional response to pain like we do.

"Also do we have a good reason for getting rid of them? With mosquitoes, they are the main carriers for many diseases."

The question is likely to remain hypothetical, whatever the level of concern over Zika, malaria and dengue. Despite the success of reducing mosquito numbers in smaller areas, many scientists say knocking out an entire species would be impossible.

"There's no silver bullet," says Hawkes. "Field trials using GM mosquitoes have been a moderate success but involved releasing millions of modified insects to cover just a small area.

"Getting every female mosquito to breed with sterile males in a large area would be very difficult. Instead we should be looking to combine this with other techniques."

Innovative ways of tackling mosquitoes are being developed across the world. Scientists at Kew Gardens in London are developing a sensor that can detect each different species of mosquito from its distinctive wing beat. They plan to equip villagers in rural Indonesia with wearable acoustic detectors to track disease-bearing mosquitoes. This would help them manage future outbreaks.

Meanwhile, scientists at the London School of Hygiene & Tropical Medicine have worked out how female mosquitoes are attracted to certain body odours, raising hope for more effective repellents.

Another promising avenue is to make mosquitoes resistant to the parasites that cause the diseases. In Australia, the Eliminate Dengue programme is using naturally occurring bacteria to reduce the ability of mosquitoes to pass dengue between people.

"This is a more realistic approach for mitigating mosquito-borne disease," says Lounibos.

Meanwhile, scientists in the US have bred a GM mosquito with a new gene in the laboratory that makes it resistant to the malaria parasite.

"We are playing an evolutionary game with mosquitoes," says Hawkes. "Hopefully it's one we can get on top of over the next 10 to 15 years."


And also: Is the world ready for GM animals?

Tags: environment, florida

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